Stephen Goff

Regulation of HIV-1 RNA synthesis and trafficking

Stephen Goff, PI

spg1@cumc.columbia.edu

Lab website

Silencing of unintegrated HIV-1 DNA; Histones and histone modifications associated with silencing; Host factors required for silencing.

Mechanisms of reactivation of latent proviruses to initiate RNA synthesis. Post-transcriptional regulation of escape from latency.

Mechanism of action of the host restriction factor ZAP in targeting and degrading viral RNAs. We will identify and characterize new host cofactors involved in stimulating ZAP activity.

Exploring the mechanisms for translational frameshifting at the Gag-Pol junction.

Probing the host regulation of viral mRNA export from the nucleus.